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DNA damage builds up over time and increases PARP activity, which uses up NAD+ reserves

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While they generally have a favorable safety profile, the specific side effects can vary between medications

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Doctors sometimes use Zofran for other types of nausea as well

Because of the risk of serious ventricular arrhythmias and sudden death potentially associated with elevated plasma levels of thioridazine, CYMBALTA and thioridazine should not be co-administered [see Drug Interactions (7.9)]